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KMID : 1143220200630030270
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Obstetrics & Gynecology Science
2020 Volume.63 No. 3 p.270 ~ p.277
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A study to compare maternal and perinatal outcome in early vs. late onset preeclampsia
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Wadhwani Pooja
Saha Pradip Kumar
Kalra Jaswinder Kaur
Gainder Shalini
Sundaram Venkataseshan
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Abstract
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Objective: The risk factors, clinical trends, and maternal and fetal health of early- and late-onset preeclampsia have not been adequately studied. We examined the effects of early- and late-onset preeclampsia on maternal and perinatal outcomes as well as the known risk factors of preeclampsia.
Methods: One hundred and fifty women with preeclampsia were consecutively enrolled in each group. Those who developed preeclampsia before 34 weeks of gestation were identified as having early-onset preeclampsia, while those who developed at 34 weeks or later were identified as having late-onset preeclampsia. Maternal and perinatal outcomes were compared between groups.
Results: Compared with the late-onset group, the early-onset group had higher rates of abruptio placentae (16% vs. 7.3%; P=0.019), but there was no intergroup difference in the composite maternal outcomes. A significantly higher number of women with early-onset preeclampsia developed severe features during the disease course, and most required treatment with antihypertensive drugs. Late-onset preeclampsia was more prevalent among primigravid mothers. Babies born to mothers with early-onset preeclampsia had a significantly higher rate of adverse outcomes.
Conclusion: These study findings indicate that women with early-onset preeclampsia had more adverse outcome than those with late-onset preeclampsia, but the difference was not statistically significant. There were more babies with adverse perinatal outcomes in the early-than late-onset group.
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KEYWORD
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Early-onset preeclampsia, Late onset preeclampsia, Maternal outcome, Perinatal outcome
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